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  • Centers for Behavioral and Preventive Medicine

  • The Weight Control and Diabetes Research Center

  • The Weight Control and Diabetes Research Center promotes research in the field of obesity prevention and treatment. The center aims to expand knowledge into the causes and consequences of obesity, develop treatments for weight loss and weight management, gain knowledge and help the community through clinical trials and provide training to the medical community in obesity research.

    Director Rena Wing, PhD, is well known for her research in effective strategies for long-term weight loss and preventative weight gain prevention in children and adults.

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    Cognitive Effects of Bariatric Surgery

    More Weight Control Resources:

    Bariatric Surgery
    Weight Management Program

    This study will examine the cognitive effects of bariatric surgery in participants from the Longitudinal Assessment of Bariatric Surgery (LABS) project. There is growing evidence that obesity is associated with adverse neurocognitive outcome. We are assessing cognitive performance in bariatric surgery patients enrolled in the LABS project and matched controls at four time points: pre-operatively, 12 weeks post-operatively, 12 months post-operatively, and 24 months post-operatively. Findings from the proposed study will provide important information regarding the cognitive effects of bariatric surgery, the possible mechanisms for these effects, and the contribution of cognitive performance to short- and long-term outcome of bariatric surgery.

    Principal Investigators:Ronald Cohen, PhD (Subcontract) and John Gunstad, PhD (Project PI)

    Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases

    Dates: 2006 - 2010

    Sleep Duration and Pediatric Overweight: The Role ofEating Behaviors

    This grant examines whether changing sleep duration in school-age children is associated with changes in leptin and ghrelin, the reinforcing value of food and eating and activity behaviors. (1-09-JF-22)

    Principal Investigator:Chantelle Hart, PhD

    Co-Investigators: Mary Carskadon, PhD; Joseph Fava, PhD; Elissa Jelalian, PhD; and Judith Owens, MD

    Funding Agency: The American Diabetes Association

    Dates: 2009 - 2011


    Recruiting and Retaining Young Adults in Behavioral Weight Loss Treatment

    The goals of this grant are twofold: 1) to use qualitative methods to conduct formative work aimed at improving recruitment and retention efforts with emerging adults, and 2) to conduct a randomized controlled trial to test the feasibility and preliminary efficacy of three different approaches to longer-term weight control with this age group. (K23 DK083440-01)

    Principal Investigator:Jessica Gokee LaRose, PhD

    Co-Investigators/Mentors: Rena R. Wing, PhD; Elissa Jelalian, PhD; Kathleen Morrow, PhD; Joseph Fava, PhD; Cora E. Lewis, MD

    Funding Agency: The National Institute of Diabetes and Digestive and Kidney Diseases

    Dates: 2009 - 2014


    The Look AHEAD Continuation: Action for Health in Diabetes

    Look AHEAD is a randomized clinical trial examining the long-term health effects of an intensive weight loss intervention in approximately 5,145 overweight volunteers with type 2 diabetes. Participants are randomized to an intensive lifestyle intervention designed to achieve and maintain weight loss by decreased caloric intake and increased physical activity, or to a control program of diabetes support and education. The primary outcome of Look AHEAD is the aggregate occurrence of severe cardiovascular events (fatal and non-fatal Ml and stroke and cardiovascular deaths) over a planned follow-up of 11.5 years. The continuation of this project allows for completion of follow up outcome assessments and the continued administration of the lifestyle intervention. These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. (5U01DK056992-11)

    Principal Investigator:Rena R. Wing, PhD

    Co-Investigators: Vincent Pera, MD; Jeanne McCaffery, PhD

    Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases and the National Institute of Nursing Research

    Dates: 1999 - 2013

    Prevention of Postpartum Weight Retention

    The primary goal of this project is to test the effects of a behavioral lifestyle intervention in promoting healthy weight gain during pregnancy and preventing postpartum weight retention.

    Principal Investigator:Rena R. Wing, PhD

    Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases

    Dates: 2006 - 2010

    Gene x Behavioral Interaction in the Look AHEAD Study

    Obesity is a major public health problem, with millions of Americans suffering from weight-related health complications, including Type 2 diabetes, coronary heart disease, hypertension and osteoarthritis. Behavioral weight loss intervention has emerged as a key strategy in combating obesity and the associated health consequences. However, individuals differ in their degree of success in these programs and genetic factors are known to play a role. We propose to identify specific genes that predict individual differences in weight loss in response to behavioral intervention to help identify individuals who struggle with weight loss despite behavioral efforts. Genotype data from the IBC chip, including over 4,000 markers within genes previously associated with obesity, will allow us to test our central hypothesis that genes that predispose to obesity interact with lifestyle treatment to influence weight loss following intensive lifestyle intervention.

    Principal Investigators:Rena Wing, PhD; Jeanne McCaffery, PhD

    Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases

    Dates: 2009-2013


    Lifestyle Intervention to Treat Erectile Dysfunction (LITE)

    The purpose of this planning grant is to plan a randomized clinical trial to test the efficacy of lifestyle intervention (weight loss and increased activity) in obese men with erectile dysfunction.

    Principal Investigator:Rena R. Wing, PhD

    Co-Investigator: Dale Bond, PhD

    Funding Agency: National Institute of Diabetes and Digestive and Kidney Diseases

    Dates: 2009 - 2011

    Prevention of Weight Gain in Young Adults

    "STOP (Study toPrevent) Weight Gain" is a randomized clinical trial testing two innovative interventions to prevent weight gain over an average 3 years of follow-up in individuals 18 to 35 years of age. This study will compare these interventions to each other and to a control condition in a 3-armed randomized controlled clinical trial.

    Principal Investigator:Rena R. Wing, PhD

    Co-Investigators: Jessica LaRose, PhD; Jeanne McCaffery, PhD

    Funding Agency: National Heart, Lung, and Blood Institute

    Dates: 2009 - 2014

    Innovative Technology to Improve Patient Adherence to Weight Loss Recommendations

    The purpose of this project is to use innovative technology to improve adherence to behavioral weight loss strategies. The program will use Web-based interactive multi-media approaches to promote behavior change and maintenance.

    Principal Investigator:Rena R. Wing, PhD

    Co-Investigators: Graham Thomas, PhD

    Funding Agency: National Heart, Lung, and Blood Institute

    Dates: 2009 - 2011

    Increasing Sleep Duration: A Novel Approach to Weight Control

    This project, which establishes the Center for Behavioral Intervention Development (CBID), seeks to translate the basic science on sleep duration into a novel intervention to reduce obesity and obesity-related co- morbidities. The project involves a programmatic series of studies to develop a sleep and weight loss intervention. The target population for these studies will be young adults (age 25 - 45) where the association between sleep duration and obesity appears strongest, who are overweight or obese (BMI 25 - 40), and who currently sleep less than six and a half hours per night. This series of studies will be used to examine the effects of increases in sleep duration alone and in combination with a weight loss program on eating and exercise behaviors (measured objectively), and ultimately on body weight. The effects of increasing sleep duration on physiological, psychological and cognitive changes that may relate to the changes in eating and activity and adherence to weight control recommendations will also be examined. The CBID creates a new interdisciplinary team, including investigators in the areas of behavioral weight control, basic and clinical aspects of sleep, fMRI and neuropsychological assessment of cognitive function, eating and exercise behavior and physiological changes associated with sleep and weight. (U01 CA150387-01)

    Principal Investigator:Rena Wing, PhD

    Co-Investigators: Dale Bond, PhD; Mary Carskadon, PhD; Robert Considine, PhD; Ron Cohen, PhD; Joseph Fava, PhD; Chantelle Hart, PhD; Jeanne McCaffery, PhD; Richard Millman, MD; George Papandonatos, PhD; Donn Posner, PhD; Hollie Raynor, PhD; Katherine Sharkey, MD; and Larry Sweet, PhD

    Funding Agency: The National Cancer Institute

    Dates: 2009 - 2014